![]() ![]() Chronic Akt blockade aggravates pathological hypertrophy and inhibits physiological hypertrophy. 2007 34: 255-262.Ĩ.ěuss SJ, Riffel JH, Malekar P, Hagenmueller M, Asel C, Zhang M, et al. Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure. Cardiac hypertrophy and thyroid hormone signaling. Signaling Mechanisms in Thyroid Hormone-Induced Cardiac Hypertrophy. Evolving concepts of left ventricular hypertrophy. Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy. Genetic determinants of cardiac hypertrophy. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. The present review article highlights the signaling mechanisms involved and the approaches required in the treatment of cardiac hypertrophy.ġ.Ěkhter SA, Luttrel LM, Rockman HA, Lacirino G, Lefkowitz RJ, Koch WJ. The prevention strategy for cardiac hypertrophy involve thiazide diuretics, angiotensin-converting enzyme (ACE) inhibitors, angiotensin (Ang) II receptor blockers, beta blockers and calcium channel blockers. Numerous mediators have been found to be involved in the pathogenesis of cardiac hypertrophy that include mitogen-activated protein kinase (MAPK), protein kinase C (PKC) insulin-like growth factor-I (IGF-I), phosphatidylinositol 3-kinase (PI3K)-AKT/PKB, calcinurin-nuclear factor of activated T cells (NFAT) and mammalian target of rapamycin (mTOR). On the other hand, reduced ability of pumping blood as a result of hypertension and volume overload on heart denotes pathological hypertrophy. The exercise-induced increase in the ability of pumping blood leads to thickening of ventricle wall, referred to as physiological hypertrophy. physiological and pathological hypertrophy. Cardiac hypertrophy has been divided into two types, i.e. Cardiac hypertrophy, a disease associated with the myocardium, is characterized by thickening of ventricle wall of heart and consequent reduction in the contracting ability of heart to pump the blood. Cardiac hypertrophy has been considered as an important risk factor for cardiac morbidity and mortality whose prevalence has increased during the last few decades. ![]()
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